Diagnostic Value of the Leukocyte Esterase Test for Early Detection of Pleocytosis in Cerebrospinal Fluid of Patients with Suspected Acute Bacterial Meningitis

Shervin Shokouhi; Mehdi Karamipour; Ilad Alavi DarazamNariman SepehrvandHasanali AhmadiMohammad M. Sajadi

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Diagnostic Value of the Leukocyte Esterase Test for Early Detection of Pleocytosis in Cerebrospinal Fluid of Patients with Suspected Acute Bacterial Meningitis

机译：Diagnostic Value of the Leukocyte Esterase Test for Early Detection of Pleocytosis in Cerebrospinal Fluid of Patients with Suspected Acute Bacterial Meningitis

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Background: Rapid and accurate diagnosis of patients with suspectedbacterial meningitis (BM) is crucial to prevent potential subsequent mortality andmorbidity. The aim of this study was to explore the diagnostic value of the rapid leukocyteesterase (LE) strip test in identifying pleocytosis in cerebrospinal fluid (CSF)samples of patients with suspected BM.Methods: A total of 126 patients with suspected meningitis were enrolled in this prospectivestudy. Microscopic examination (cell count and differential) and leukocyteesterase (LE) rapid strip test were performed on cerebrospinal fluid (CSF) samples.Sensitivity, specificity, positive predictive value and negative predictive value of theLE test were determined.Results: Fifty-two patients (41%) had pleocytosis in the CSF, while 48 (38%) patientshad a positive rapid LE strip test result. The diagnostic accuracy of this test forpleocytosis was translated to a sensitivity of 84.6% (95%CI 71.9, 93.1) and a specificityof 94.5% (95%CI 86.7, 98.5), with an area under the receiver operating curveof 0.88.Conclusion: The LE strip test, through rapid and accurate determination of CSF pleocytosis,could be considered as an additional test in the diagnosis of bacterial meningitis.It can be tested at bedside and is feasible to do in resource-limited settings.

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《Infectious disorders drug targets》 |2018年第1期|29-34|共6页
作者
Shervin Shokouhi; Mehdi Karamipour; Ilad Alavi DarazamNariman SepehrvandHasanali AhmadiMohammad M. Sajadi;
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作者单位

Clinical Research Development Center of Loghman Hakim Hospital, Shahid Beheshti University of;

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, United States;

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of MedicalDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Meningitis; leukocyte esterase; pleocytosis; rapid strip test; CSF pleocytosis;

Diagnostic Value of the Leukocyte Esterase Test for Early Detection of Pleocytosis in Cerebrospinal Fluid of Patients with Suspected Acute Bacterial Meningitis

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