Targeted Delivery of Apoptotic Cell-Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation

Ju-Ro Lee; Woo-Sup Sim; Hun-Jun ParkBong-Woo ParkYoon Ki Joung

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Targeted Delivery of Apoptotic Cell-Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation

机译：Targeted Delivery of Apoptotic Cell-Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation

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The modulation of inflammatory responses plays an important role in thepathobiology of cardiac failure. In a natural healing process, the ingestion ofapoptotic cells and their apoptotic bodies by macrophages in a focal lesionresult in resolution of inflammation and regeneration. However, therapeuticstrategies to enhance this natural healing process using apoptotic cell-derivedbiomaterials have not yet been established. In this study, apoptotic bodiesmimeticnanovesicles derived from apoptotic fibroblasts (ApoNVs) conjugatedwith dextran and ischemic cardiac homing peptide (CHP) (ApoNV-DCs) forischemia-reperfusion (IR)-injured heart treatment are developed. Intravenouslyinjected ApoNV-DCs actively targeted the ischemic myocardium viaconjugation with CHP, and are selectively phagocytosed by macrophages inan infarcted myocardium via conjugation with dextran. ApoNV-DCs polarizedmacrophages from the M1 to M2 phenotype, resulting in the attenuationof inflammation. Four weeks after injection, ApoNV-DCs attenuated cardiacremodeling, preserved blood vessels, and prevented cardiac function exacerbationin IR-injured hearts. Taken together, the findings may open a new avenuefor immunomodulation using targeted delivery of anti-inflammatory nanovesiclesthat can be universally applied for various inflammatory diseases.

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《Advanced functional materials》 |2023年第23期|2210864.1-2210864.12|共12页
作者
Ju-Ro Lee; Woo-Sup Sim; Hun-Jun ParkBong-Woo ParkYoon Ki Joung;
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Center for BiomaterialsBiomedical Research InstituteKorea Institute of Science and TechnologySeoul 02792, Republic of Korea;

Department of Biomedicine & Health SciencesThe Catholic University of Korea, Republic of KoreaSeoul 06591, Republic of Korea Division of CardiologyDepartment of Internal MedicineSeoul St. Mary’s HospitalThe Catholic University of KoreaSeoul 06591, Republi;

Department of Biomedicine & Health SciencesThe Catholic University of Korea, Republic of KoreaSeoul 06591, Republic of KoreaDepartment of Biomedicine & Health SciencesThe Catholic University of Korea, Republic of KoreaSeoul 06591, Republic of Korea Catholic High-Performance Cell Therapy Center and Departmentof Medical Life ScienceCollege of MedicineThe Catholic University of KCenter for BiomaterialsBiomedical Research InstituteKorea Institute of Science and TechnologySeoul 02792, Republic of Korea Division of Bio-Medical Science and TechnologyUniversity of Science and Technology, Republic of KoreaSeoul 02792, Republic of Korea;

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anti-inflammation; apoptotic bodies; cardiac repairs; myocardial infarction; targeted delivery;

Targeted Delivery of Apoptotic Cell-Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation

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