AbstractDaughter cells arising from a single cell division in the leukemic cell line K562 have equivalent self‐renewal potential with respect to their ability to form clones in semisolid medium. However, individual cells isolated from these clones in sequence have vastly different abilities in their self‐renewal potentials. Thus, cells originating from a clone with any particular self‐renewal potential exhibit the full range of self‐renewal potentials–‐from highly renewing to none renewing, cells. These results show that self‐renewal potential in the K562 cell line is a random, reversible and partially noninherited characteristic. It is suggested that the stochastic variability of the intraclonal self‐renewal potential of K562 progeny cells either reflects the initial expression of a differentiation program or the expression of the predeterministic portion of the normal myelopoietic differen
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