Indeterminate thyroid nodules can present a confounding scenario for both provider and patient. Once a diagnosis of an indeterminate thyroid nodule is made, appropriate management can range from conservative observation to surgical resection. A thorough evaluation, including a dedicated history and physical examination, biochemical profile, pathologic information from a seasoned pathologist, and thyroid ultrasound by an experienced radiologist can help point health-care providers in the right direction. However, the ultimate diagnosis cannot be rendered unless surgical excision is performed. Provider and patient must agree on a personalized risk vs. benefit profile for the indeterminate thyroid nodule.
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