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>Effect of some ergosterol biosynthesis inhibiting fungicides on sterols and cytochrome P‐450 from the Japanese quailCoturnix coturnix
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Effect of some ergosterol biosynthesis inhibiting fungicides on sterols and cytochrome P‐450 from the Japanese quailCoturnix coturnix
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机译：Effect of some ergosterol biosynthesis inhibiting fungicides on sterols and cytochrome P‐450 from the Japanese quailCoturnix coturnix
AbstractNine fungicides that inhibit ergosterol biosynthesis (diclobutrazol, fenarimol, fenpropimorph, imazalil, nuarimol, prochloraz, propiconazole, triadimefon, triadimenol) and one plant growth regulator (ancymidol) were administered to Japanese quails (Coturnix coturnix). Most of these compounds had a moderate or no effect, but prochloraz, imazalil and, to a lesser extent, propiconazole were shown to produce a dramatic increase in liver weight and cytochrome P‐450 level. These three compounds were also found to be potent in‐vitro inhibitors of 7‐ethoxycoumarin O‐de‐ethylase and aniline hydroxylase, thus resulting in a biphasic effect on drug‐metabolising enzymes. With these three compounds, and some others, an accumulation of lanosterol in liver was also observed, suggesting an inhibition of stero
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