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首页> 外文期刊>Journal of thermal analysis and calorimetry >Some physico-chemical properties of doxazosin mesylate polymorphic forms and its amorphous state
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Some physico-chemical properties of doxazosin mesylate polymorphic forms and its amorphous state

机译：Some physico-chemical properties of doxazosin mesylate polymorphic forms and its amorphous state

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Seven polymorphic modifications of doxazosin mesylate, designed as forms A, D, E, F, G, H, I, and the amorphous state were studied by thermal methods (TG and DSC), temperature resolved X-ray powder diffractometry, hot stage and scanning electron microscopy and by FT-IR spectroscopy. Amorphous form was obtained either by fast evaporation of the solvent or by fast cooling of the melt in the DSC. Polymorphs A and F were found to be stable in the temperature range from room temperature to their melting points at 277.9 and 276.5 ℃, respectively. From G, which melts at 270.8 ℃, was found to be hygroscopic. Polymorph D undergoes irreversible solid-liquid-solid phase transition at 235.5 ℃ to polymorph I which melts at 274.9 ℃. Form H, which melts at 258.0 ℃. was found to be unstable at high temperatures. DSC examinations revealed that form H is irreversibly transformed to polymorph F during heating above the temperature of about 240 ℃. The amorphous state was found to be stable at room temperature but when heating above the glass transition (T_g = 144.1 ℃) it crystallizes at 221.6 ℃, what leads into a mixture of polymorphic forms. The new polymorphic form designed as E was identified in the mixture. The polymorph E is converted by heating to the more stable form F. The solubilities at 25 ℃ for forms A, and F in methanol are 3.5 and 7.7 mg mL~(-1) and in water they are 3.8 and 6.2 mg mL~(-1), respectively.

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