A Smart Silk-Based Microneedle for Cancer Stem Cell Synergistic Immunity/Hydrogen Therapy

Jingbo Yang; Guangmeng Li; Jun YuanSibo JingXiangjiang WangFanwen YangYang LiuYoude DingGang LiGuoxi XieAilin TaoMing LiuMaobin Xie

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A Smart Silk-Based Microneedle for Cancer Stem Cell Synergistic Immunity/Hydrogen Therapy

机译：A Smart Silk-Based Microneedle for Cancer Stem Cell Synergistic Immunity/Hydrogen Therapy

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Cancer stem cells (CSCs) are responsible for the melanoma recurrence, progression,and ineffective therapy. Despite striking anti-CSCs results in immunotherapywith anti-programmed death-1 antibodies (aPD-1), the therapeuticefficacy is restricted by the evolution of immune evasion of CSCs. Here, awearable silk-based microneedle device (SMND) integrating a synergisticimmunity and hydrogen therapy is developed. The device mainly consists of adouble-layered MN patch (DLMNP), which employs aPD-1 loaded silk fibroin(SF) as the inner matrix for immunotherapy, while ammonia borane-loadedmesoporous silica nanoparticles (AB-MSN) encapsulated polycaprolactoneas the outer thermal-responsive coating for H_2 releasing. SMND can realizethermally responsive drug release triggered by a smartphone for a sustainedanti-CSCs therapy. In B16F10-CSCs bearing mice melanoma models, theresults demonstrates that the synergistic treatment strategy can realizea satisfying antitumor and anti-CSCs efficacy, which is accompanied by aminimized systemic toxicity. In summary, the smart and synergistic anti-CSCsfeatures endow SMND as a highly functional platform, which can be potentiallyextended to chronic disease therapy.

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来源
《Advanced functional materials》 |2022年第41期|2206406.1-2206406.17|共17页
作者
Jingbo Yang; Guangmeng Li; Jun YuanSibo JingXiangjiang WangFanwen YangYang LiuYoude DingGang LiGuoxi XieAilin TaoMing LiuMaobin Xie;
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Affiliated Cancer Hospital and Institute of Guangzhou MedicalUniversityGuangzhou Municipal and Guangdong ProvincialKey Laboratory of Protein Modification and DegradationSchool of Basic Medical ScienceGuangzhou Medical UniversityGuangzhou 511436, China;

The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalGuangzhou Municipal and Guangdong ProvincialKey Laboratory of Protein Modification and DegradationSchool of Biomedical EngineeringGuangzhou Medical UniversityGuangzhou;

The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518, P. R. ChinaThe Second Affiliated HospitalThe State Key Laboratory of Respiratory DiseaseProvincial Key Laboratory of Allergy & Clinical ImmunologyGuangzhou Medical UniversityGuangzhou 510260, ChinaThe Second Affiliated HospitalThe State Key Laboratory of Respiratory DiseaseProvincial Key Laboratory of Allergy & Clinical ImmunologyGuangzhou Medical UniversityGuangzhou 510260, China, National Engineering Laboratory for Modern SilkCollege of Textile a;

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正文语种英语
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hydrogen therapy; immunotherapy; microneedles; silk; smartphone;

A Smart Silk-Based Microneedle for Cancer Stem Cell Synergistic Immunity/Hydrogen Therapy

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