The Association Between HIV Status, Estradiol, and Sex Hormone Binding Globulin Among Premenopausal Women in the Women's Interagency HIV Study

Sally B. Coburn; Jodie Dionne-Odom; Maria L. AlcaideCaitlin A. MoranLisa RahangdaleElizabeth T. GolubLeslie Stewart MassadDominika SeidmanKatherine G. MichelHoward MinkoffKerry MurphyTodd T. BrownKala VisvanathanBryan LauKeri N. Althoff

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The Association Between HIV Status, Estradiol, and Sex Hormone Binding Globulin Among Premenopausal Women in the Women's Interagency HIV Study

机译：The Association Between HIV Status, Estradiol, and Sex Hormone Binding Globulin Among Premenopausal Women in the Women's Interagency HIV Study

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Background: Characterizing estradiol among women with HIV may have implications for breast cancer and cardiovascular disease risk but has not been adequately explored. We quantified differences in total (E2), free (FE2) estradiol, and sex hormone binding globulin (SHBG) by HIV and viral suppression status.Methods: Women from a substudy (2003–2006) within the Women's Interagency HIV Study (IRB approved at each participating site) were included if they reported: a period in the last six months, were not pregnant/breastfeeding, no oophorectomy, and no exogenous hormone use in the prior year. Serum was collected on days 2–4 of the menstrual cycle. We assessed differences in biomarkers at 25th, 50th, and 75th percentiles by HIV and viral suppression status using weighted quantile regression.Results: Among 643 women (68% with HIV) median age was 37 years. All E2 percentiles were significantly (p p Conclusions: There were no differences in FE2 but significantly lower E2 and higher SHBG among women with HIV versus without HIV. Further research is merited in a large contemporary sample to clarify the clinical implications of these findings.

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《Journal of women’s health》 |2022年第2期|183-193|共11页
作者
Sally B. Coburn; Jodie Dionne-Odom; Maria L. AlcaideCaitlin A. MoranLisa RahangdaleElizabeth T. GolubLeslie Stewart MassadDominika SeidmanKatherine G. MichelHoward MinkoffKerry MurphyTodd T. BrownKala VisvanathanBryan LauKeri N. Althoff;
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Department of Epidemiology, Johns Hopkins University;

Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham;

Department of Medicine, Miller School of Medicine, University of MiamiDivision of Infectious Diseases, Department of Medicine, Emory University School of MedicineDivision of General Obstetrics and Gynecology, Department of Obstetrics and Gynecology, UniversityDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington UniversityDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California SanDivision of Infectious Diseases, Department of Medicine, School of Medicine, Georgetown UniversityDepartment of Obstetrics and Gynecology, Maimonides Medical Center and SUNY DownstateDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of MedicineDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University;

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正文语种英语
中图分类妇幼卫生;
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HIV; premenopausal women; estradiol; SHBG;

The Association Between HIV Status, Estradiol, and Sex Hormone Binding Globulin Among Premenopausal Women in the Women's Interagency HIV Study

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