Integrating music-based interventions with Gamma-frequency stimulation: Implications for healthy ageing

Tichko P.; Kim J.C.; Large E.Loui P.

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Integrating music-based interventions with Gamma-frequency stimulation: Implications for healthy ageing

机译：Integrating music-based interventions with Gamma-frequency stimulation: Implications for healthy ageing

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In recent years, music-based interventions (MBIs) have risen in popularity as a non-invasive, sustainable form of care for treating dementia-related disorders, such as Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). Despite their clinical potential, evidence regarding the efficacy of MBIs on patient outcomes is mixed. Recently, a line of related research has begun to investigate the clinical impact of non-invasive Gamma-frequency (e.g., 40 Hz) sensory stimulation on dementia. Current work, using non-human-animal models of AD, suggests that non-invasive Gamma-frequency stimulation can remediate multiple pathophysiologies of dementia at the molecular, cellular and neural-systems scales, and, importantly, improve cognitive functioning. These findings suggest that the efficacy of MBIs could, in theory, be enhanced by incorporating Gamma-frequency stimulation into current MBI protocols. In the current review, we propose a novel clinical framework for non-invasively treating dementia-related disorders that combines previous MBIs with current approaches employing Gamma-frequency sensory stimulation. We theorize that combining MBIs with Gamma-frequency stimulation could increase the therapeutic power of MBIs by simultaneously targeting multiple biomarkers of dementia, restoring neural activity that underlies learning and memory (e.g., Gamma-frequency neural activity, Theta-Gamma coupling), and actively engaging auditory and reward networks in the brain to promote behavioural change.

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《The European journal of neuroscience.》 |2022年第12期|3303-3323|共21页
作者
Tichko P.; Kim J.C.; Large E.Loui P.;
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Department of Music, Northeastern University, Boston, MA, United States;

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正文语种英语
中图分类神经病学与精神病学;
关键词
ageing; Alzheimer's disease; dementia; Gamma stimulation; music-based interventions; neural oscillations;

Integrating music-based interventions with Gamma-frequency stimulation: Implications for healthy ageing

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