Reduce, Retain, Recycle: Mechanisms for Promoting Histone Protein Degradation versus Stability and Retention

Hogan Ann K.; Foltz Daniel R.

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Reduce, Retain, Recycle: Mechanisms for Promoting Histone Protein Degradation versus Stability and Retention

机译：Reduce, Retain, Recycle: Mechanisms for Promoting Histone Protein Degradation versus Stability and Retention

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The eukaryotic genome is packaged into chromatin. The nucleosome, the basic unit of chromatin, is composed of DNA coiled around a histone octamer. Histones are among the longest-lived protein species in mammalian cells due to their thermodynamic stability and their associations with DNA and histone chaperones. Histone metabolism plays an integral role in homeostasis. While histones are largely stable, the degradation of histone proteins is necessary under specific conditions. Here, we review the physiological and cellular contexts that promote histone degradation. We describe specific known mechanisms that drive histone proteolysis. Finally, we discuss the importance of histone degradation and regulation of histone supply for organismal and cellular fitness.

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《Molecular and Cellular Biology》 |2021年第6期|共17页
作者
Hogan Ann K.; Foltz Daniel R.;
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Northwestern Univ;

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正文语种英语
中图分类分子生物学;
关键词
DNA replication; chaperone; chromatin; histone; nucleosome; nucleus; posttranslational modification; transcription; CENP-A NUCLEOSOMES; POSTTRANSLATIONAL MODIFICATIONS; CORE HISTONES; MALE GERMLINE; H3 VARIANT; CHROMATIN REPLICATION; DNA-REPLICATION; CELL FATE; IN-VIVO; CHAPERONE;

Reduce, Retain, Recycle: Mechanisms for Promoting Histone Protein Degradation versus Stability and Retention

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