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首页> 外文期刊>Infectious disorders drug targets >Systematic Review and Meta-analysis of Carbapenem Resistance of Acinetobacter baumannii in Iran Bentham Science
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Systematic Review and Meta-analysis of Carbapenem Resistance of Acinetobacter baumannii in Iran Bentham Science

机译：Systematic Review and Meta-analysis of Carbapenem Resistance of Acinetobacter baumannii in Iran Bentham Science

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摘要

Background: The prevalence of carbapenem resistance in Acinetobacter baumannii hasbeen increasing worldwide, and therapeutic options are extremely limited. We performed a systematicreview to evaluate the phenotypic and genotypic carbapenem resistance in A.baumanniireported in Iran.Methods: We systematically searched Pub Med, Web of Science Direct, and Google scholar databasesto identify studies addressing the carbapenem resistance of A. baumannii. The selected paperswere published between 2005 and 2016, but the sample collection period was between 2002and 2016. To estimate the prevalence, the Der Simonian and Laird randomized models, a 95%confidence interval, was used. For the heterogeneity check, I2 test was used. The Egger test wasused to check the propagation bias.Results: Analysis of data indicates that there was an increase in resistance to carbapenems from4.5% in 2005 to a 100% prevalence rate in 2016 (65.4 (95% CI: 58.8 – 71.6).Conclusion: According to the results of this study, the rate of resistance to carbapenem inA.baumannii has been increasing in Iran. The presence of carbapenem-resistant isolates is a majorconcern, because carbapenem is the main drug used against Multi Drug Resistant (MDR) isolates.

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