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Multienzyme nanoassemblies: from rational design to biomedical applications

机译:Multienzyme nanoassemblies: from rational design to biomedical applications

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摘要

Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for multiple applications. Considerable progress has been made to design and fabricate MENAs in recent years. This review begins with an introduction of the up-to-date strategies in designing MENAs, mainly including substrate channeling, compartmentalization and control of enzyme stoichiometry. The desirable properties that endow MENAs with important applications are also discussed in detail. Then, the recent advances in utilizing MENAs in the biomedical field are reviewed, with a particular focus on biosensing, tumor therapy, antioxidant and drug delivery. Finally, the challenges and perspectives for development of versatile MENAs are summarized.

著录项

  • 来源
    《Biomaterials Science》 |2021年第22期|7323-7342|共20页
  • 作者单位

    Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China;

    Nanyang Technol Univ, Sch Chem & Biomed Engn, 70 Nanyang Dr, Singapore 637457, Singapore;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 分子生物学;
  • 关键词

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