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Mitochondrion-Targeting Peptides and Peptidomimetics: Recent Progress and Design Principles

机译：线粒体靶向肽和肽模拟物的研究进展和设计原理

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摘要

Mitochondria are multifunctional subcellular organelles whose operations encompass energy production, signal transduction, and metabolic regulation. Given their wide range of roles, they have been studied extensively as a potential therapeutic target for the treatment of various diseases, including cancer, diabetes, and neurodegenerative diseases. Mitochondrion-mediated pathways have been identified as promising targets in the context of these diseases. However, the delivery of specific probes and drugs to the mitochondria is one of the major problems that remains to be solved. Over the past decade, much effort has been devoted to developing mitochondrion-targeted delivery methods based on the membrane characteristics and the protein import machinery of mitochondria. While various methods utilizing small molecules to polymeric particles have been introduced, it is notable that many of these compounds share common structural elements and physicochemical properties for optimal selectivity and efficiency. In this Perspective, we will review the most recently developed mitochondrion-targeting peptides and peptidomimetics to outline the key aspects of structural requirements and design principles. We will also discuss successful and potential applications of mitochondrial delivery to assess opportunities and challenges in the targeting of mitochondria.
机译：线粒体是多功能亚细胞器，其操作包括能量产生、信号转导和代谢调节。鉴于它们的广泛作用，它们已被广泛研究为治疗各种疾病的潜在治疗靶点，包括癌症、糖尿病和神经退行性疾病。线粒体介导的通路已被确定为这些疾病背景下的有希望的靶点。然而，将特定的探针和药物输送到线粒体是尚待解决的主要问题之一。近十年来，基于线粒体的膜特性和蛋白质输入机制，开发线粒体靶向递送方法。虽然已经引入了各种利用小分子聚合物颗粒的方法，但值得注意的是，这些化合物中的许多具有共同的结构元素和物理化学特性，以实现最佳的选择性和效率。在本观点中，我们将回顾最近开发的线粒体靶向肽和拟肽，以概述结构要求和设计原则的关键方面。我们还将讨论线粒体递送的成功和潜在应用，以评估靶向线粒体的机遇和挑战。

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  • 来源
    《Biochemistry》 |2020年第3期|270-284|共15页
  • 作者

    Kim Soyoung; Nam Ho Yeon; Lee JiyounSeo Jiwon;

  • 作者单位

    Gwangju Inst Sci & Technol, Sch Phys & Chem, Dept Chem, Gwangju 61005, South Korea;

    Sungshin Univ, Dept Global Med Sci, Seoul 01133, South Korea;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 生物化学;
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