NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse

Se-ChanOh; Seong-EunKim; In-HwanJangSeok-MinKimSoo YunLeeSunyoungLeeIn-SunChuSuk RanYoonHaiyoungJungInpyoChoiJunsangDohTae-DonKim

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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse

机译：NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse

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The formation of an immunological synapse is central to the ability of NK cells to lyse target cells. Here the authors show that Nogo receptor 1 (NgR1) might be a good target for cancer immunotherapy as it destabilizes the NK synapse, resulting in defective killing of tumor cells.

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《Nature immunology》 |2023年第3期|463-473|共11页
作者
Se-ChanOh; Seong-EunKim; In-HwanJangSeok-MinKimSoo YunLeeSunyoungLeeIn-SunChuSuk RanYoonHaiyoungJungInpyoChoiJunsangDohTae-DonKim;
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作者单位

Immunotherapy Research Center,Korea Research Institute of Bioscience and Biotechnology;

Department of Mechanical Engineering,Pohang University of Science and Technology;

Korea Research Institute of Bioscience and BiotechnologyDepartment of Materials Science and Engineering,Research Institute of Advanced Materials, Institute;

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正文语种英语
中图分类医学免疫学;
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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse

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