...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Decidual vasculopathy and spiral artery remodeling revisited II: relations to trophoblastic dependent and independent vascular transformation
【24h】

Decidual vasculopathy and spiral artery remodeling revisited II: relations to trophoblastic dependent and independent vascular transformation

机译：Decidual vasculopathy and spiral artery remodeling revisited II: relations to trophoblastic dependent and independent vascular transformation

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Background: There are three types of decidual vasculopathy at term, acute atherosis, fibrinoid medial necrosis, and mural arterial hypertrophy with two separate mechanisms. Acute atherosis and fibrinoid medial necrosis demonstrate the replacement of the muscular wall by the fibrinoid material and “foamy cells”, whereas mural arterial hypertrophy depicts thickened hypertrophic muscular wall with a narrowed lumen. Methods: In this review, decidual vasculopathy is reexamined using the knowledge of CD56 expression on endovascular trophoblasts (EVTs) at term with perspective in diagnosis and pathogenesis. Results: All three types of vasculopathy can be identified in both decidua basalis and decidua vera (capsularis/parietalis) at term. Decidual vasculopathy at basalis is related to the persistence of EVTs in spiral artery remodeling at implantation and phenotypic switch to express CD56. However, no trophoblastic invasion of spiral artery is present at decidua vera. At implantation, the spiral artery undergoes a trophoblastic-dependent remodeling in decidua basalis whereas the spiral artery undergoes trophoblastic-independent remodeling in decidual vera. Conclusions: Decidual vasculopathy at term is related to spiral artery remodeling at implantation and this is associated with factors other than trophoblastic invasion alone. The spiral artery remodeling at implantation and pathogenesis of decidual vasculopathy at term is likely through circulating factors in relation to complex physiological and pathological conditions in pregnancy. ? 2020 Informa UK Limited, trading as Taylor & Francis Group.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号