Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model

Nota Takehito; Kageyama Ken; Yamamoto AkiraKakehashi AnnaYonezawa HirokiJogo AtsushiSohgawa EtsujiMurai KazukiOgawa SatoyukiMiki Yukio

首页> 外文期刊>Academic radiology >Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model

【24h】

Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model

机译：Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Rationale and Objectives: Safety and feasibility of contrast-enhanced computed tomography (CECT) with a nanoparticulate contrast agent, ExiTron nano 12000, was evaluated in a rat liver tumor model.Materials and Methods: This study employed eighteen 8-week-old male F344 rats. Six rats given tap water for 8 weeks further divided into two: Control group and Normal Liver with CECT group. Six rats each were given tap water containing diethylnitrosamine (DEN) at 100 ppm for 8 or 14 weeks; Adenoma group and Hepatocellular carcinoma (HCC) group, respectively. Biochemical marker values and adverse events were evaluated after CT imaging. ExiTron nano 12000 was evaluated for the hepatic contrast enhancement, and the detec-tion and measurement of liver nodules by CECT after 8-and 14-weeks administration of DEN. Post-mortem liver specimens were evalu-ated by hematoxylin-eosin (HE) staining, and the number and size of liver nodules were measured. The HCC group was evaluated for diagnostic concordance between HE-stained and CECT-detected nodules.Results: The contrast agent enhanced liver and was tolerated after CECT in 15 rats. Biochemical parameter values did not differ signifi-cantly between the Control and Normal Liver groups. The numbers of CECT-detected nodules in the Adenoma and HCC groups were 14.8 +/- 5.1, and 32.4 +/- 8.1, respectively. The HCC group had 3.6 +/- 2.7 of pathological HCCs, which were identified by CECT. The size of CECT-detected HCCs correlated significantly with that of pathological HCCs (r = 0.966, p < 0.0001).Conclusion: CECT with ExiTron nano 12000 is a safe and feasible method to measure tumors in a rat liver tumor model.

著录项

来源
《Academic radiology》 |2023年第1期|30-39|共10页
作者
Nota Takehito; Kageyama Ken; Yamamoto AkiraKakehashi AnnaYonezawa HirokiJogo AtsushiSohgawa EtsujiMurai KazukiOgawa SatoyukiMiki Yukio;
展开▼
作者单位

Dept Diagnost & Intervent Radiol,Grad Sch Med;

Grad Sch Med,Osaka City Univ;

Osaka Metropolitan University,Osaka Metropolitan Univ;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类放射医学;
关键词
Contrast Media; Diethylnitrosamine; Hepatocellular Carcinoma; Rats; X-Ray Computed Tomography; HEPATOCELLULAR-CARCINOMA; MICRO-CT; ABLATION; SORAFENIB; SPLEEN; IMAGE;

Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model

摘要

著录项

相关主题

期刊订阅