High-Strength Hydroxyapatite Scaffolds with Minimal Surface Macrostructures for Load-Bearing Bone Regeneration

Qiang Zhang; Limin Ma; Xiongfa JiYue HeYue CuiXuemin LiuChengkai XuanZhenxing WangWei YangMuyuan Chaiand Xuetao Shi

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High-Strength Hydroxyapatite Scaffolds with Minimal Surface Macrostructures for Load-Bearing Bone Regeneration

机译：High-Strength Hydroxyapatite Scaffolds with Minimal Surface Macrostructures for Load-Bearing Bone Regeneration

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Triply periodic minimum surfaces (TPMS), which outperform other structuresin terms of bulk moduli and relative density, have been widely used to dramaticallyimprove the mechanical strength of natural echinoderm skeletons andengineered scaffolds. Herein, TPMS-structure-based 3D-printed hydroxyapatite(Hap) scaffolds to highly improve their limited mechanical strengthand evaluate the underlying mechanism in terms of mechanical match andbiological bone repair process as a bone regeneration scaffold are constructed.The results show that TPMS-structure-based Hap scaffolds have a greatercompressive strength range that is sufficient to meet the strength requirementsfor human cortical and trabecular bone, and outperform traditionalHap scaffolds with Cross-hatch structures in terms of compressive strength,cell density, and osteogenic differentiation. The reduction of stress concentrationand open-cell permeable structure of Split-P scaffolds can benefit the generationand ingrowth of new bone after the in vivo implantation in the rabbitfemur bone. Furthermore, RNA-seq and immunochemistry staining resultsof in vivo samples unravel the bone repair mechanism in a time sequence.The optimized scaffolds with TPMS macrostructures and an in-depth understandingof repair mechanisms will contribute to the development of boneregeneration materials that perform on par with load-bearing bone.

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《Advanced functional materials》 |2022年第33期|2204182.1-2204182.12|共12页
作者
Qiang Zhang; Limin Ma; Xiongfa JiYue HeYue CuiXuemin LiuChengkai XuanZhenxing WangWei YangMuyuan Chaiand Xuetao Shi;
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National Engineering Research Centre for Tissue Restorationand ReconstructionSouth China University of TechnologyGuangzhou 510640, P. R. China,School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640, P. R. China;

Medical Research CenterGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080, P. R. China;

Medical Research CenterGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080, P. R. China,School of MedicineSouth China University of TechnologyGuangzhou 510006, P. R. ChinaNational Engineering Research Centre for Tissue Restorationand ReconstructionSouth China University of TechnologyGuangzhou 510640, P. R. China,First Affiliated Hospital of Shenzhen UniversityReproductive Medicine CentreShenzhen Second People’s HospitalSheNational Engineering Research Centre for Tissue Restorationand ReconstructionSouth China University of TechnologyGuangzhou 510640, P. R. China,School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640, P. R. China;

GuaNational Engineering Research Centre for Tissue Restorationand ReconstructionSouth China University of TechnologyGuangzhou 510640, P. R. China,School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640, P. R. China;

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正文语种英语
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bone formation; hydroxyapatites; mechanical strength; minimal surfaces; osteogenesis;

High-Strength Hydroxyapatite Scaffolds with Minimal Surface Macrostructures for Load-Bearing Bone Regeneration

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