Antibiotic-Derived Carbon-Nanodot-Decorated Hydrogel for Reactive Oxygen Species-Enhanced Anti-Infection Through Biofilm Damage

Zekun Wang; Pu Zhang; Chenyang YinYuqing LiZiyu LiaoChenhao YangHang LiuWeiyun WangCundong FanDongdong SunLiang Cheng

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Antibiotic-Derived Carbon-Nanodot-Decorated Hydrogel for Reactive Oxygen Species-Enhanced Anti-Infection Through Biofilm Damage

机译：Antibiotic-Derived Carbon-Nanodot-Decorated Hydrogel for Reactive Oxygen Species-Enhanced Anti-Infection Through Biofilm Damage

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Irreversible bacterial resistance and impenetrable biofilms have rendered conventionalantibiotic therapy ineffective. Nevertheless, increasing evidence hasconfirmed that antibiotic carbon nanodots (CDs) exhibit potent antibacterialactivity. However, the complex chemical composition of antibiotic CDs, and,hence, their antibacterial mechanism, is difficult to understand. The designof new antibiotic CDs against antibacterial resistance is an urgent requirement.In this study, kanamycin-sulfate-derived carbon nanodots (KCDs) arefound to exhibit significant antibacterial potential with the assistance of lightirradiation. Systematic analysis indicates that KCDs not only retain the activestructure of kanamycin but also produce five new components modified onits surface, which are shown to inhibit the activity of Staphylococcus aureusbeta-ketoacyl-acp synthase Ⅲ (FabH) through molecular docking. Furthermore,the multifunctional hydrogels (CG-KCDs) self-assemble into injectable,self-healing, and antibiofilm structures through noncovalent forces betweenthe KCDs and cationic guar gum (CG). The results indicate that under laser,CG-KCDs irradiation exhibits enhanced antibacterial activity in vitro bydamaging bacterial biofilms in a reactive oxygen species (ROS)-dependentmanner, as determined by transcriptomics. Further, the therapeutic effects ofCG-KCDs hydrogel dressings on wound healing and tissue remodeling underlaser are confirmed using an in vivo wound infection model. These resultsvalidate the potential of KCDs as efficient antibacterial agents to replace antibioticsas an anti-infective strategy.

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《Advanced functional materials》 |2023年第29期|2300341.1-2300341.17|共17页
作者
Zekun Wang; Pu Zhang; Chenyang YinYuqing LiZiyu LiaoChenhao YangHang LiuWeiyun WangCundong FanDongdong SunLiang Cheng;
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Department of Cardiovascular MedicineAffiliated Taian City Central Hospital of Qingdao UniversityTaian, Shandong 271000, China;

School of Life SciencesAnhui Agricultural UniversityHefei, Anhui 230036, China;

Shandong Key Laboratory of TCM Multi-Target Interventionand Disease ControlThe Second Affiliated Hospital of Shandong First Medical UniversityTaian, Shandong 271000, ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu KeyLaboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123, China;

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正文语种英语
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antibiotic-derived carbon nanodots; anti-infection; biofilms; hydrogels; reactive oxygen species; wound healing;

Antibiotic-Derived Carbon-Nanodot-Decorated Hydrogel for Reactive Oxygen Species-Enhanced Anti-Infection Through Biofilm Damage

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