Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function

Tang Jeffry S.; Cait Alissa; Li YanyanAbolins-Thompson HelenaGell KatieHerst Patries M.OSullivan DavidGasser Olivier

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Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function

机译：Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function

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The ligand-activated aryl hydrocarbon receptor (AhR) is an important molecular regulator of immune function, whose activity can be modulated by dietary glucosinolate- and tryptophan-derived metabolites. In contrast, the potential use of polyphenols as dietary regulators of AhR-dependent immunity remains unclear. In this perspective, we discuss how cellular metabolism may alter the net effect of polyphenols on AhR, thus potentially reconciling some of the conflicting observations reported in the literature. We further provide a methodological roadmap, across the fields of immunology, metabolomics, and gut microbial ecology, to explore the potential effects of polyphenol-rich diets on AhR-regulated immune function in humans.

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《Journal of Agricultural and Food Chemistry》 |2021年第31期|8625-8633|共9页
作者
Tang Jeffry S.; Cait Alissa; Li YanyanAbolins-Thompson HelenaGell KatieHerst Patries M.OSullivan DavidGasser Olivier;
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作者单位

Malaghan Inst Med Res, Wellington 6242, New Zealand;

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原文格式 PDF
正文语种英语
中图分类营养卫生、食品卫生;农业科学;
关键词
nutritional immunology; aryl hydrocarbon receptor (AhR); polyphenols; mucosal and systemic immunity; metabolism;

Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function

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