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Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

机译：Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

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摘要

Intervertebral disc (IVD) degeneration is the leading cause of low back pain,which represents a highly prevalent chronic aging-associated disorder with alarge socio-economic burden and a great decline in the quality of life, contributingto the pressing need for IVD treatments. Thus, finding effectivedisease-modifying approaches for postponing the progression of IVD degenerationand repairing degenerated intervertebral discs is of great importance,even facing various challengeable obstacles. Bioactive functional materialsexhibit excellent advances in modulating cell activity and remodeling tissuehomeostasis, which acts as a promising and accessible therapeutic approachto tissue repair and organ reconstruction. Recently, these have been notablyexplored to investigate bioactive functional materials-based repair strategiesfor intervertebral disc recovery and regeneration, including cell-based tissueengineering, the development of implants for disc recovery, and therapeuticmethods for remodeling the functional integrity of the IVD. This review summarizesthe advanced progress of bioactive functional materials in IVD repairand regeneration, and discusses their regulatory mechanisms, limitations,challenges as well as their clinical translational prospects in the future.

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