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首页> 外文期刊>Infectious disorders drug targets >Antimicrobial Resistance and Presence of Class 1 Integrons Among Different Serotypes of Salmonella spp. Recovered From Children with Diarrhea in Tehran, Iran
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Antimicrobial Resistance and Presence of Class 1 Integrons Among Different Serotypes of Salmonella spp. Recovered From Children with Diarrhea in Tehran, Iran

机译：Antimicrobial Resistance and Presence of Class 1 Integrons Among Different Serotypes of Salmonella spp. Recovered From Children with Diarrhea in Tehran, Iran

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Background: Salmonellosis is a major food-borne disease worldwide. The increasingprevalence of antimicrobial resistance among food-borne pathogens such as Salmonella spp. isconcerning.Objective: The main objective of this study is to identify class 1 integron genes and to determineantibiotic resistance patterns among Salmonella isolates from children with diarrhea.Methods: A total of 30 Salmonella isolates were recovered from children with diarrhea. The isolateswere characterized for antimicrobial susceptibility and screened for the presence of class 1integron genes (i.e. intI1, sulI1, and qacEΔ1).Results: The most prevalent serotype was Enteritidis 36.7%, followed by Paratyphi C (30%), andTyphimurium (16.7%). The highest rates of antibiotic resistance were obtained for nalidixic acid(53.3%), followed by streptomycin (40%), and tetracycline (36.7%). Regarding class 1 integrons,36.7%, 26.7%, and 33.3% of the isolates carried intI1, SulI, and qacEΔ1, respectively, most ofwhich (81.8%) were multidrug-resistant (MDR). Statistical analysis revealed that the presence ofclass 1 integron was significantly associated with resistance to streptomycin and tetracycline (p =0.042). However, there was no association between class 1 integron and other antibiotics used inthis study (p > 0.05).Conclusion: The high frequency of integron class 1 gene in MDR Salmonella strains indicatesthat these mobile genetic elements are versatile among different Salmonella serotypes, and associatedwith reduced susceptibility to many antimicrobials.

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