Synthesis of novel pyrimido4,5-dpyrimidine derivatives from 5-acetyl-4-aminopyrimidines

Komkov Alexander V; Kozlov Mikhail A.; Prezent Mikhail A.Dmitrenok Andrey S.Kolotyrkina Natalya G.Minyaev Mikhail E.Zavarzin Igor V

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Synthesis of novel pyrimido4,5-dpyrimidine derivatives from 5-acetyl-4-aminopyrimidines

机译：Synthesis of novel pyrimido4,5-dpyrimidine derivatives from 5-acetyl-4-aminopyrimidines

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摘要

Two routes were proposed for the synthesis of pyrimido[4,5-d]pyrimidine derivatives from 5-acetyl-4-aminopyrimidines. Acylation of 5-acetyl-4-aminopyrimidines followed by cyclization by the action of NH4OAc made it possible to access pyrimido[4,5-d]pyrimidines with alkyl, aryl, and hetaryl substituents in positions 2 and 7. Reductive amination of the acetyl group in 5-acetyl-4-aminopyrimidines and subsequent cyclization with DMF-DMA or HC(OEt)(3) resulted in the formation of 6-alkyl-3,4-dihydropyrimido[4,5-d]pyrimidines.

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来源
《Chemistry of heterocyclic compounds》 |2022年第5期|243-250|共8页
作者
Komkov Alexander V; Kozlov Mikhail A.; Prezent Mikhail A.Dmitrenok Andrey S.Kolotyrkina Natalya G.Minyaev Mikhail E.Zavarzin Igor V;
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Russian Acad Sci;

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正文语种英语
中图分类杂环化合物;
关键词
5-acetyl-4-aminopyrimidines; 3; 4-dihydropyrimido4; 5-dpyrimidines; pyrimido4; heterocyclization; reductive amination; BETA-DICARBONYL COMPOUNDS; CYCLIZATION; INHIBITION;

Synthesis of novel pyrimido4,5-dpyrimidine derivatives from 5-acetyl-4-aminopyrimidines

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