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首页> 外文期刊>Annals of Human Genetics >Contribution of gender-specific genetic factors to osteoporosis risk.
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Contribution of gender-specific genetic factors to osteoporosis risk.

机译：性别特异性遗传因素对骨质疏松症风险的贡献。

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摘要

Common diseases result from the complex relationship between genetic and environmental factors. The aim of this review is to provide perspective for a conceptual framework aimed at studying the interplay of gender-specific genetic and environmental factors in the etiology of complex disease, using osteoporosis as an example. In recent years, gender differences in the heritability of the osteoporosis-related phenotypes have been reported and sex-specific quantitative-trait loci were discovered by linkage studies in humans and mice. Results of numerous allelic association studies also differed by gender. In most cases, it was not clear whether or not this phenomenon should be attributed to the effect of sex-chromosomes, sex hormones, or other intrinsic or extrinsic differences between the genders, such as the level of bioavailable estrogen and of physical activity. We conclude that there is need to consider gender-specific genetic and environmental factors in the planning of future association studies on the etiology of osteoporosis and other complex diseases prevalent in the general population.
机译：常见疾病是由遗传和环境因素之间的复杂关系造成的。这篇综述的目的是提供一个概念框架的视角，以骨质疏松症为例，研究复杂疾病的病因中特定于性别的遗传和环境因素之间的相互作用。近年来，已经报道了骨质疏松症相关表型的遗传力中的性别差异，并且通过在人和小鼠中的连锁研究发现了性别特异性的数量性状基因座。众多等位基因关联研究的结果也因性别而异。在大多数情况下，尚不清楚这种现象是否应归因于性染色体，性激素或性别之间的其他内在或外在差异，例如生物可利用的雌激素水平和体育活动的影响。我们得出的结论是，在规划有关普通人群中普遍存在的骨质疏松症和其他复杂疾病的病因的未来关联研究时，需要考虑针对性别的遗传和环境因素。

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