Co-Exposure of Phenanthrene and the cyp-lnducer 3-Methykhrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae

Elin Sorhus; Prescilla Perrichon; Charlotte L. Nakken

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Co-Exposure of Phenanthrene and the cyp-lnducer 3-Methykhrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae

机译：Co-Exposure of Phenanthrene and the cyp-lnducer 3-Methykhrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae

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Polycyclic aromatic hydrocarbons (PAHs) have frequently been suspected of governing crude oil toxicity because of similar morphological defects in fish. However, PAH concentrations are often not high enough to explain the observed crude oil toxicity. We hypothesize that one PAH can enhance the metabolism and toxicity of another PAH when administered as a mixture. Early life stage Atlantic haddock (Melanogrammus aegkfinus) were in this study exposed to phenanthrene in the presence and absence of 3-methylchrysene that is known to induce the metabolic enzyme cytochrome P450 1A via cypla gene expression. Uptake, metabolism, and multiple toxicity endpoints were then measured in a time-course study up to 3 days post-hatching. Passive dosing provided aqueous concentrations =180 ug/L for phenanthrene and =0.6ug/L for 3-methylchrysene, which resulted in tissue concentrations =60 ug/g ww for phenanthrene and =0.15 ug/g ww for 3-methylchrysene. The low concentration of 3-metliylchrysene led to the elevated expression of cypla but no toxicity. Levels of phenanthrene metabolites were 5-fold higher, and morphological defects and cardiotoxicity were consistently greater when co-exposed to both compounds relative to phenanthrene alone. This work highlights the metabolic activation of PAH toxicity by a co-occurring PAH, which can lead to excess toxicity, synergistic effects, and the overproportional contribution of PAHs to crude oil toxicity.

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《Environmental Science & Technology: ES&T》 |2023年第30期|11022-11031|共10页
作者
Elin Sorhus; Prescilla Perrichon; Charlotte L. Nakken;
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作者单位

Reproduction and Developmental Biology, Institute of Marine Research, Austevoll Research Station, 5392 Storebe, Norway;

Department of Chemistry, University of Bergen, 5007 Bergen, Norway;

Marine Toxicology, Institute of Marine Research, 5004 Bergen, Norway;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
mixture toxicity; crude oil; cypla; early life stage fish; allcyl-PAHs; haddock; metabolism;

Co-Exposure of Phenanthrene and the cyp-lnducer 3-Methykhrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae

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