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>Studies on carcinogenesis by avian sarcoma viruses. V. Requirement for new DNA synthesis and for cell division
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Studies on carcinogenesis by avian sarcoma viruses. V. Requirement for new DNA synthesis and for cell division
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机译：Studies on carcinogenesis by avian sarcoma viruses. V. Requirement for new DNA synthesis and for cell division
AbstractPartially synchronized secondary cultures of chicken embryo fibroblasts were exposed to Rous sarcoma virus (RSV) at various times in the cell cycle. The initiation of normal virus production could be inhibited by treatment with excess thymidine or with cytosine arabinoside without any effect on mitosis. This result is consistent with the hypothesis that the provirus of RSV is DNA, although the virion of RSV contains only RNA. It was, also, found that treatment which prevented or interferred with the first mitosis after exposure to virus prevented the initiation of normal virus production. Later mitoses did not appear to be necessary. A corollary of this finding is that virus production is synchronized by mitosis and that the length of the latent period depends upon when in the cell cycle a cell is exposed to virus.
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