Associations of Fine Particulate Matter Constituents with Metaboli* Syndrome and the Mediating Role of Apolipoprotein B:A Multicenter Study in Middle-Aged and Elderly Chinese Adults

Weizhuo Yi; Feng Zhao; Rubing Pan

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Associations of Fine Particulate Matter Constituents with Metaboli* Syndrome and the Mediating Role of Apolipoprotein B:A Multicenter Study in Middle-Aged and Elderly Chinese Adults

机译：Associations of Fine Particulate Matter Constituents with Metaboli* Syndrome and the Mediating Role of Apolipoprotein B:A Multicenter Study in Middle-Aged and Elderly Chinese Adults

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Fine particulate matter(PM_(2.5))was reported to be associated with metabolic syndrome(MetS),but how PM_(2.5)constituents affect MetS and the underlying mediators remains unclear.We aimed to investigate the associations of long-term exposure to 24 kinds of PM_(2.5)constituents with MetS(defined by five indicators)in middle-aged and elderly adults and to further explore the potential mediating role of apolipoprotein B(ApoB).A multicenter study was conducted by recruiting subjects(n = 2045)in the Beijing-Tianjin-Hebei region from the cohort of Sub-Clinical Outcomes of Polluted Air in China(SCOPA-China Cohort).Relationships among PM_(2.5)constituents,serum ApoB levels,and MetS were estimated by multiple logistic/linear regression models.Mediation analysis quantified the role of ApoB in"PM_(2.5)constituents-MetS"associations.Results indicated PM_(2.5)was significantly related to elevated MetS prevalence.The MetS odds increased after exposure to sulfate(SO_4~(2-)),calcium ion(Ca~(2+)),magnesium ion(Mg~(2+)),Si,Zn,Ca,Mn,Ba,Cu,As,Cr,Ni,or Se(odds ratios ranged from 1.103 to 3.025 per interquartile range increase in each constituent).PM_(2.5)and some constituents(SO_4~(2-),Ca~(2+),Mg~(2+),Ca,and As)were positively related to serum ApoB levels.ApoB mediated 22.10% of the association between PM_(2.5)and MetS.Besides,ApoB mediated 24.59%,50.17%,12.70%,and 9.63% of the associations of SO_4~(2-),Ca~(2+),Ca,and As with MetS,respectively.Our findings suggest that ApoB partially mediates relationships between PM_(2.5)constituents and MetS risk in China.

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《Environmental Science & Technology: ES&T》 |2022年第14期|10161-10171|共11页
作者
Weizhuo Yi; Feng Zhao; Rubing Pan;
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作者单位

Department of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,Hefei,Anhui 230031,China;

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei,Anhui 230031,China;

Department of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,Hefei,Anhui 230031,China;

China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
PM_(2.5)constituents; Metabolic syndrome; Apolipoprotein B; Mediation analysis;

Associations of Fine Particulate Matter Constituents with Metaboli* Syndrome and the Mediating Role of Apolipoprotein B:A Multicenter Study in Middle-Aged and Elderly Chinese Adults

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