Nontarget Identification of Novel Per-and Polyfluoroalkyl Substances in Cord Blood Samples

Xiaowen Xia; Yuxin Zheng; Xiaowen Tang

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Nontarget Identification of Novel Per-and Polyfluoroalkyl Substances in Cord Blood Samples

机译：Nontarget Identification of Novel Per-and Polyfluoroalkyl Substances in Cord Blood Samples

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Per-and polyfluoroalkyl substances(PFASs)can penetrate the placental barrier and reach embryos through cord blood,probably causing adverse birth outcomes.Therefore,novel PFASs identification in cord blood and their relationships with birth outcomes are essential to evaluate prenatal exposure risk of PFASs.Herein,16 legacy and 12 novel PFASs were identified in 326 cord blood samples collected from pregnant women in Jinan,Shandong,China.The presence of perfluoropolyether carboxylic acids,hydrogen-substituted polyfluoroetherpro-pane sulfate,and 3:3 chlorinated polyfluoroalkyl ether alcohol in cord blood was reported for the first time.Two extensive OECD(Organization for Economic Cooperation and Development)-defined PFASs named fipronil sulfone and 2-chloro-6-(trifluoromethyl)pyridine-3-ol were also identified.Quantification results showed that the emerging and OECD-defined PFASs separately accounted for 9.4 and 9.7% of the total quantified PFASs,while the legacy PFOA,PFOS,and PFHxS were still the most abundant PFASs with median concentrations of 2.12,0.58,and 0.37 ng/mL,respectively.Several PFASs(C9-C_(11)PFCAs,C6-C8 PFSAs,and 6:2 Cl-PFESA)showed significantly higher levels for older maternities than younger ones.PFHxS levels were positively associated with birth weight and ponderal index(p < 0.05).The results provide comprehensive information on the presence and exposure risks of several novel PFASs during the early life stage.

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《Environmental Science & Technology: ES&T》 |2022年第23期|17061-17069|共9页
作者
Xiaowen Xia; Yuxin Zheng; Xiaowen Tang;
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作者单位

Department of Occupational Health and Environmental Health,School of Public Health,Qingdao University,Qingdao 266071,China;

Department of Medicinal Chemistry,School of Pharmacy,Qingdao University,Qingdao 266071,China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
per-and polyfluoroalkyl substances; emerging contaminants; umbilical cord blood; nontarget screening prenatal exposure risk;

Nontarget Identification of Novel Per-and Polyfluoroalkyl Substances in Cord Blood Samples

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