Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy

Yoji Hirai; Hideo Asada; Toshihisa HamadaJun‐ichi KawadaHiroshi KimuraAyako AraiKoichi OhshimaShouichi OhgaKeiji Iwatsuki

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Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy

机译：Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy

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Abstract Hydroa vacciniforme lymphoproliferative disorder (HV‐LPD) and severe mosquito bite allergy (SMBA) are both cutaneous forms of Epstein–Barr virus (EBV)‐associated T/natural killer (NK) cell LPDs and are closely related to chronic active EBV disease (CAEBV) and EBV‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH). HV‐LPD is further divided into classic HV, a benign subtype mediated by EBV‐positive γδT cells, and systemic HV, another life‐threatening subtype mainly associated with EBV‐positive αβT or γδT cells. The vast majority of patients with SMBA have increased numbers of EBV‐infected NK cells in the blood. Clinical symptoms of HV‐LPD and SMBA often overlap in the same patient and may progress to more serious disease conditions equivalent to the systemic form of CAEBV. To define the disease spectrum of HV‐LPD and SMBA, we propose the diagnostic criteria and the determination criteria for disease severity. The proposed diagnostic criteria are consistent with those for CAEBV and EBV‐HLH in the guidelines for the management for CAEBV and related disorders 2023.

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《The Journal of dermatology》 |2023年第7期|e198-e205|共8页
作者
Yoji Hirai; Hideo Asada; Toshihisa HamadaJun‐ichi KawadaHiroshi KimuraAyako AraiKoichi OhshimaShouichi OhgaKeiji Iwatsuki;
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作者单位

Department of Dermatology, Department of Dermatology,Okayama University Graduate School of Medicine;

Department of Dermatology,Nara Medical University School of Medicine;

Department of Dermatology,International University of Health and WelfareDepartment of Pediatrics,Nagoya University Graduate School of MedicineDepartment of Virology,Nagoya University Graduate School of MedicineDivision of Hematology and Oncology, Department of Internal Medicine,St. Marianna University SchoolDepartment of Pathology, School of Medicine,Kurume UniversityDepartment of Pediatrics, Graduate School of Medical Sciences,Kyushu University;

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正文语种英语
中图分类皮肤病学与性病学;
关键词
diagnostic criteria; disease spectrum; Epstein–Barr virus; hydroa vacciniforme lymphoproliferative disorder; severe mosquito bite allergy;

Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy

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