Cuproptosis-Driven Enhancement of Thermotherapy by Sequentially Response Cu_(2-x)Se via Copper Chemical Transition

Leung Chan; Yongkang Liu; Muhe ChenYanhong SuJunxian GuoLiwen ZhuMeixiaoZhanTianfeng ChenLigong Lu

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Cuproptosis-Driven Enhancement of Thermotherapy by Sequentially Response Cu_(2-x)Se via Copper Chemical Transition

机译：Cuproptosis-Driven Enhancement of Thermotherapy by Sequentially Response Cu_(2-x)Se via Copper Chemical Transition

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Activation of cuproptosis pathway has been reported to hold great potentialin the application of tumor treatment. But the efficacy of cuproptosis seriouslylimited by the insufficient accumulation in the tumor sites. Therefore,herein based on the strong stabilization effects of the metalloid elementselenium (Se) on copper (Cu), a photothermic Cu_(2-x)Se nanoparticle encapsulatedwith bioresponsive dimethyl maleic anhydride (DMMA@Cu_(2-x)Se) as acopper-carrier to improve the copper accumulation in tumor is constructed,thus achieving cuproptosis-driven enhancement of thermotherapy. Thisnanosystem exhibits the enhancement of tumor cellular uptake by a weakacid-triggered charge-switching ability. Next step, the exposed Cu_(2-x)Se isoxidized and releases divalent copper by high-level oxide. Then, the abundantcopper induces more dihydrolipoamide S-acetyltransferase oligomerizationto down-regulate FDX1 and tricarboxylic acid cycle-related proteins, whichleads to inhibiting aerobic respiration. Cuproptosis-induced mitochondrialdamage further improves thermotherapy by up-regulating reactive oxygenspecies (ROS). In addition, the generated ROS also promotes copper releaseto strengthen cuproptosis, and eventually improves tumor thermotherapy inturn. In general, DMMA@Cu_(2-x)Se with sequentially triggered copper-release,efficient cuproptosis, and appropriate photothermal is a self-enhanced nanoplatformfor cuproptosis-driven enhancement of thermotherapy.

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来源
《Advanced functional materials》 |2023年第33期|2302054.1-2302054.13|共13页
作者
Leung Chan; Yongkang Liu; Muhe ChenYanhong SuJunxian GuoLiwen ZhuMeixiaoZhanTianfeng ChenLigong Lu;
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作者单位

Guangdong Provincial Key Laboratory of Tumor InterventionalDiagnosis and TreatmentZhuhai People’s Hospital (Zhuhai hospital affiliated with JinanUniversity)Jinan UniversityGuangdong 519000, China,Department of ChemistryJinan UniversityGuangzhou 510632, China;

Guangdong Provincial Key Laboratory of Tumor InterventionalDiagnosis and TreatmentZhuhai People’s Hospital (Zhuhai hospital affiliated with JinanUniversity)Jinan UniversityGuangdong 519000, China;

Department of ChemistryJinan UniversityGuangzhou 510632, China;

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正文语种英语
中图分类无线电电子学、电信技术;工程材料学;
关键词
Cu_(2-x)Se nanoparticle; copper chemical transition; cuproptosis; sequential bioresponse; thermotherapy;

Cuproptosis-Driven Enhancement of Thermotherapy by Sequentially Response Cu_(2-x)Se via Copper Chemical Transition

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