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首页> 外文期刊>Infectious disorders drug targets >Outcomes of Treatment and Predictors of Response to Sofosbuvir Plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection
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Outcomes of Treatment and Predictors of Response to Sofosbuvir Plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection

机译：Outcomes of Treatment and Predictors of Response to Sofosbuvir Plus Simeprevir in Hepatitis C Virus with Genotype-4 Infection

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Background & Aims: Treatment plan of chronic HCV infection has dramatically improvedafter the introduction of different groups of Direct-Acting Antiviral (DAA) drugs. Thesedrugs have been found to be safe and effective. Sofosbuvir (SOF) plus simeprevir (SMV) regimenhas been shown to be tolerable and effective in treatment of patients with HCV genotype 1. Theaim of the study was to evaluate the safety and the efficacy of combined sofosbuvir plus simeprevirtreatment in genotype 4 chronic HCV patients.Methods: This open-label multicenter prospective study was carried out on 381 Egyptian patientswith chronic hepatitis C virus- infection. Treatment experienced and treatment-naive patients wereincluded. Subjects administrated a regimen of sofosbuvir (400 mg/ day) plus semiprevir (150 mg/day) for twelve weeks. Sustained Virological Response (SVR) was confirmed by undetectableHCV RNA by quantitative PCR 3 months after the end of the treatment.Results: 97.6% (372 /381) of patients had SVR. None of the studied clinical and demographiccharacteristics were associated with the SVR status. However, patients who failed to achieve SVRshowed low albumin level and high total leucocyte. The most common side effects of the studiedregimen were headache, fatigue, itching, photosensitivity, and cough.Conclusions: Twelve weeks’ regimen of sofosbuvir plus simeprevir was considered to be safe andtolerable in the treatment of HCV genotype 4; also it was associated with high SVR (97.6%).

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