Due to the semitrusted cloud, privacy protection of medical images in medical imaging clouds has become a precondition. For the privacy of patients and the security of medical images in the cloud, this paper proposes a selective encryption based on DNA sequence and chaotic maps for skin lesion image. Initially, we design a transition region-based level set evolution functional which is merged into a variational level set expression with two extra energy functionals, to segment skin lesion image. Once skin lesion detection has been performed, the detected skin lesion pixels are encrypted by employing chaotic systems and DNA sequences. We apply 2D-LASM and 1D-LSS to produce the pseudorandom sequences and use the hash function of the plaintext image to calculate the secret keys of the encryption system. Results demonstrate that the proposed segmentation method is particularly suitable for the detection of skin lesion images with strong noise and complex background. Meanwhile, security analysis also reveals that this selective encryption has a large security key space and high sensitivity to the plaintext image and the secret key.
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