Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations

Maryam Kavousi Heidari; Mehrab Pourmadadi; Fatemeh YazdianHamid RashediSayed Ali Seyyed EbrahimiZohreh BagherMona Navaei‐NigjehBibi Fatemeh Haghirosadat

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Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations

机译：Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations

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Abstract Silk fibroin (SF), extracted from Bombyx mori, has unique physicochemical properties to achieve an efficient wound dressing. In this study, reduced graphene oxide (RGO)/ZnO NPs/silk fibroin nanocomposite was made, and an innovative nanofiber of SF/polyvinyl alcohol (PVA)/RGO/ZnO NPs was ready with the electrospinning technique and successfully characterized. The results of MIC and OD analyses were used to investigate the synthesized materials' antibacterial effects and displayed that the synthesized materials could inhibit growth against Staphylococcus aureus and Escherichia coli bacteria. However, both in vitro cytotoxicity (MTT) and scratch wound studies have shown that RGO/ZnO NPs and SF/PVA/RGO/ZnO NPs are not only non‐toxic to NIH 3T3 fibroblasts, but also can cause cell viability, cell proliferation, and cell migration. Furthermore, improving the synthesized nanofiber's structural properties in the presence of RGO and ZnO NPs has been confirmed by performing tensile strength, contact angle, and biodegradation analyses. Also, in a cell attachment analysis, fibroblast cells had migrated and expanded well in the nanofibrous structures. Moreover, in vivo assay, SF/PVA/RGO/ZnO NPs nanofiber treated rats and has been shown significant healing activity and tissue regeneration compared with other treated groups. Therefore, this study suggests that SF/PVA/RGO/ZnO NPs nanofiber is a hopeful wound dressing for preventing bacteria growth and improving superficial wound repair.

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《Biotechnology Progress》 |2023年第3期|n/a-n/a|共17页
作者
Maryam Kavousi Heidari; Mehrab Pourmadadi; Fatemeh YazdianHamid RashediSayed Ali Seyyed EbrahimiZohreh BagherMona Navaei‐NigjehBibi Fatemeh Haghirosadat;
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作者单位

University of Tehran;

Iran University of Medical Sciences;

The Institute of Pharmaceutical Science (TIPS), Tehran University of Medical ScienceShahid Sadoughi University of Medical Sciences;

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正文语种英语
中图分类生物科学;
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antibacterial activity; proliferation; silk fibroin; wound healing; zinc oxide nanoparticles;

Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations

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