A nomogram for preoperative prediction of microvascular invasion in ruptured hepatocellular carcinoma

FengXia; QiaoZhang; ElijahNdhlovuJunZhengHengyiGaoGuobingXia

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A nomogram for preoperative prediction of microvascular invasion in ruptured hepatocellular carcinoma

机译：A nomogram for preoperative prediction of microvascular invasion in ruptured hepatocellular carcinoma

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Microvascular invasion (MVI) is defined as the presence of micrometastatic cancer cell emboli in hepatic vessels, including small vessels, and at present, researchers believe that is an important factor for early postoperative recurrence and survival. Here, we developed and validated a preoperative predictive model for the presence of MVI in patients with ruptured hepatocellular carcinoma (rHCC). We retrospectively collected data for 210 rHCC patients who underwent staged hepatectomy at Wuhan Tongji Hospital, and 91 patients who underwent staged hepatectomy at Zhongshan People’s Hospital between January 2010 and March 2021. Then, the former was used as the training cohort and the latter was used as the validation cohort. Logistic regression was used to screen for variables associated with MVI, and these variables were used to construct nomograms. We used R software to assess the discrimination, calibration ability, as well as clinical efficacy of nomograms. Multivariate logistic regression analysis identified four risk factors independently associated with MVI: max tumor length [odds ratio (OR)?=?1.385; 95% confidence interval (CI), 1.072–1.790], number of tumors (OR?=?2.182; 95% CI, 1.129–5.546), direct bilirubin (OR?=?1.515; 95% CI, 1.189–1.930), and alpha-fetoprotein (cutoff?=?400?ng/mL) (OR?=?2.689; 95% CI, 3.395–13.547). Nomograms were built from the four variables and they were tested for discrimination and calibration, and the results were good. We developed and validated a preoperative predictive model for the presence of MVI in patients with ruptured HCC. This model can help clinicians identify patients at risk of MVI and make better treatment options.

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《European journal of gastroenterology and hepatology》 |2023年第5期|591-599|共9页
作者
FengXia; QiaoZhang; ElijahNdhlovuJunZhengHengyiGaoGuobingXia;
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Department of Hepatic Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of;

Department of Emergency Medicine, Zhongshan People’s Hospital Affiliated to Guangdong Medical;

Department of Science and Education, Shenzhen Baoan District People’s Hospital, GuangdongDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen Longhua District People’s HospitalDepartment of Hepatobiliary and Pancreatic Surgery, Huangshi Central Hospital of Edong Healthcare;

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中图分类消化系及腹部疾病;
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A nomogram for preoperative prediction of microvascular invasion in ruptured hepatocellular carcinoma

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