Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors

Florian Missey; Mary J. Donahue; Pascal WeberIbrahima NgomEmma AcerboBoris BotzanowskiLudovico MigliaccioViktor JirsaEric Daniel G?owackiand Adam Williamson

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Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors

机译：Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors

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Deep brain stimulation (DBS) is a technique commonly used both in clinical andfundamental neurosciences. Classically, brain stimulation requires an implantedand wired electrode system to deliver stimulation directly to the target area.Although techniques such as temporal interference (TI) can provide stimulationat depth without involving any implanted electrodes, these methods still relyon a wired apparatus which limits free movement. Herein organic photocapacitorsas untethered light-driven electrodes which convert deep-red light intoelectric current are reported. Pairs of these ultrathin devices can be driven usinglasers at two different frequencies to deliver stimulation at depth via temporallyinterfering fields. This concept of laser TI stimulation using numerical modeling,tests with phantom brain samples, and finally in vivo tests is validated. Wirelessorganic photocapacitors are placed on the cortex and elicit stimulation inthe hippocampus, while not delivering off-target stimulation in the cortex. Thislaser-driven wireless TI evokes a neuronal response at depth that is comparableto control experiments induced with deep brain stimulation protocols usingimplanted electrodes. This work shows that a combination of these two techniques—temporal interference and organic electrolytic photocapacitors—providesa reliable way to target brain structures requiring neither deeply implantedelectrodes nor tethered stimulator devices. The laser TI protocol demonstratedhere addresses two of the most important drawbacks in the field of DBS andthus holds potential to solve many issues in freely moving animal experimentsor for clinical chronic therapy application.

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《Advanced functional materials》 |2022年第33期|2200691.1-2200691.8|共8页
作者
Florian Missey; Mary J. Donahue; Pascal WeberIbrahima NgomEmma AcerboBoris BotzanowskiLudovico MigliaccioViktor JirsaEric Daniel G?owackiand Adam Williamson;
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Institut de Neurosciences des Systèmes (INS)INSERMUMR_1106Aix-Marseille Université13005 Marseille, France;

Laboratory of Organic ElectronicsCampus Norrk?pingLink?ping University60221 Norrk?ping, Sweden;

Central European Institute of TechnologyBrno University of TechnologyPurkyňova 123, 61200 Brno, Czech RepublicInstitut de Neurosciences des Systèmes (INS)INSERMUMR_1106Aix-Marseille Université13005 Marseille, France,Center for Bioelectronic MedicineDepartment of MedicineKarolinska InstitutetSolna, 1716 Stockholm, Sweden;

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deep brain stimulation; optoelectronics; organic bioelectronics; organic electrolytic photocapacitors; temporal interference;

Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors

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