Strategies for optimizing acetyl-CoA formation from glucose in bacteria

Zhu Li; Zhang Jieze; Yang JiaweiJiang YuYang Sheng

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Strategies for optimizing acetyl-CoA formation from glucose in bacteria

机译：Strategies for optimizing acetyl-CoA formation from glucose in bacteria

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Acetyl CoA is an important precursor for various chemicals. We provide a metabolic engineering guideline for the production of acetyl-CoA and other end products from a bacterial chassis. Among 13 pathways that produce acetyl-CoA from glucose, 11 lose carbon in the process, and two do not. The first 11 use the Embden-Meyerhof-Pamas (EMP) pathway to produce redox cofactors and gain or lose ATP. The other two pathways function via phosphoketolase with net consumption of ATP, so they must therefore be combined with one of the 11 glycolytic pathways or auxiliary pathways. Optimization of these pathways can maximize the theoretical acetyl-CoA yield, thereby minimizing the overall cost of subsequent acetyl-CoA-derived molecules. Other strategies for generating hyper-producer strains are also addressed.

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来源
《Trends in biotechnology》 |2022年第2期|149-165|共17页
作者
Zhu Li; Zhang Jieze; Yang JiaweiJiang YuYang Sheng;
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作者单位

Shanghai Laiyi Ctr Biopharmaceut R&D;

Univ Southern Calif;

Univ Chinese Acad SciChinese Acad Sci;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种英语
中图分类普通生物学;
关键词
PYRUVATE-DEHYDROGENASE COMPLEXES; OMEGA-3 EICOSAPENTAENOIC ACID; ESCHERICHIA-COLI; NONOXIDATIVE GLYCOLYSIS; PHOSPHOKETOLASE PATHWAY; YARROWIA-LIPOLYTICA; LACTOCOCCUS-LACTIS; MEVALONATE PATHWAY; CARBON METABOLISM; NADH INHIBITION;

Strategies for optimizing acetyl-CoA formation from glucose in bacteria

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