The biochemical versatility of sulfur (S) lends itself to myriad roles in plant- pathogen interactions. This review evaluates the current understanding of mechanisms by which pathogens acquire S from their plant hosts and high-lights new evidence that plants can limit S availability during the immune re-sponses. We discuss the discovery of host disease-susceptibility genes related to S that can be genetically manipulated to create new crop resistance. Finally, we summarize future research challenges and propose a research agenda that leverages systems biology approaches for a holistic understand-ing of this important element's diverse roles in plant disease resistance and susceptibility.
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