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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Recent Advances on Lacto-N-neotetraose, a Commercially AddedHuman Milk Oligosaccharide in Infant Formula
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Recent Advances on Lacto-N-neotetraose, a Commercially AddedHuman Milk Oligosaccharide in Infant Formula

机译：Recent Advances on Lacto-N-neotetraose, a Commercially AddedHuman Milk Oligosaccharide in Infant Formula

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摘要

Human milk oligosaccharides (HMOs) act as the important prebiotics and display many unique health effects forinfants. Lacto-N-neotetraose (LNnT), an abundant HMO, attracts increasing attention because of its unique beneficial effects toinfants and great commercial importance. It occurs in all groups of human milk, but the concentration generally decreases graduallywith the lactation period. It has superior prebiotic property for infants, and its other health effects have also been verified, includingbeing immunomodulatory, anti-inflammatory, preventing necrotizing enterocolitis, antiadhesive antimicrobials, antiviral activity, andpromoting maturation of intestinal epithelial cells. Safety evaluation and clinical trial studies suggest that LNnT is safe and well-tolerant for infants. It has been commercially added as a functional ingredient in infant formula. LNnT can be synthesizedviachemical, enzymatic, or cell factory approachs, among which the metabolic engineering-based cell factory synthesis is considered tobe the most practical and effective. In this article, the occurrence and physiological effects of LNnT were reviewed in detail, thesafety evaluation and regulation status of LNnT were described, various approaches to LNnT synthesis were comprehensivelysummarized and compared, and the future perspectives of LNnT-related studies were provided.

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