Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT

Ruggeri Loredana; Vago Luca; Eikema Diderik-Jande Wreede Liesbeth C.Ciceri FabioDiaz Miguel AngelLocatelli FrancoJindra PavelMilone GiuseppeDiez-Martin Jose LuisPerez-Simon Jose AntonioMerluzzi MaraKoster Lindavan der Werf Steffievan Biezen AnjaToubert AntoineNagler ArnonChabannon ChristianBonini ChiaraVelardi Andrea

首页> 外文期刊>Bone marrow transplantation >Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT

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Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT

机译：Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT

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Human leukocyte antigen (HLA) class-I mismatches that trigger donor-versus-recipient natural killer (NK)-cell alloreactivity reduce the incidence of leukemia relapse and improve survival of acute myeloid leukemia patients after T-cell-depleted HLA-haplotype mismatched ("haploidentical") hematopoietic transplantation. In murine graft-versus-host disease (GvHD) models, alloreactive NK-cells also prevent GvHD. Here we report the results of a non-interventional, prospective study performed on behalf of the Cellular Therapy and Immunobiology Working Party of the European Society for Blood and Marrow Transplantation. The study was aimed at re-assessing the role of NK-cell alloreactivity in a cohort of haploidentical transplants performed in Europe between 2012 and 2015 and composed of unmanipulated, as well as T-cell-depleted transplants. One hundred thirty-eight patients with acute myeloid or lymphoid leukemias were analyzed. Eighty-six patients received ex-vivo T-cell-depleted transplants, 52 patients received unmanipulated transplants. Fifty patients were transplanted from NK alloreactive donors, 88 from non-NK alloreactive donors. NK cell alloreactivity did not impact on GvHD/relapse-free survival (GRFS) in unmanipulated transplants (HR: 1.66 (0.9-3.1), p = 0.1). In contrast, it did impact beneficially on GRFS in T-cell-depleted transplants (HR: 0.6, (0.3-1.2), p = 0.14, interaction p < 0.001). This effect was the consequence of reduced incidences of acute and chronic GvHD and non-relapse mortality.

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《Bone marrow transplantation》 |2021年第8期|1900-1907|共8页
作者
Ruggeri Loredana; Vago Luca; Eikema Diderik-Jande Wreede Liesbeth C.Ciceri FabioDiaz Miguel AngelLocatelli FrancoJindra PavelMilone GiuseppeDiez-Martin Jose LuisPerez-Simon Jose AntonioMerluzzi MaraKoster Lindavan der Werf Steffievan Biezen AnjaToubert AntoineNagler ArnonChabannon ChristianBonini ChiaraVelardi Andrea;
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Univ Perugia, Perugia, Italy;

Osped Ferrarotto, Catania, Italy;

Osped San Raffaele, Milan, ItalyEBMT Stat Unit, Leiden, NetherlandsLeiden Univ, Dept Biomed Data Sci, Med Ctr, Leiden, NetherlandsNino Jesus Childrens Hosp, Madrid, SpainIRRCS Osped Pediat Bambino Gesu, Rome, ItalyCharles Univ Hosp, Plzen, Czech RepublicHosp Gregorio Maranon, Madrid, SpainHosp Univ Virgen Rocio, Seville, SpainEBMT Data Off Leiden, Leiden, NetherlandsUniv Paris Diderot, Hop St Louis, AP HP, INSERM U1160, Paris, FranceChaim Sheba Med Ctr, Tel Hashomer, IsraelUniv Aix Marseille, Inst Paoli Calmettes, Ctr Lutte Canc, Ctr Invest Clin Biotherapie,Inserm CBT;

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正文语种英语
中图分类治疗学;
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Natural killer cell alloreactivity in HLA-haploidentical hematopoietic transplantation: a study on behalf of the CTIWP of the EBMT

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