Usefulness of Controlled Attenuation Parameter for Identification and Grading of Nonalcoholic Fatty Liver Disease in Adolescents with Obesity

Anand Abhinav; Shalimar; Jana ManishaKandasamy DevasenathipathyKumar BrijeshSingh GajendraJain Vandana

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Usefulness of Controlled Attenuation Parameter for Identification and Grading of Nonalcoholic Fatty Liver Disease in Adolescents with Obesity

机译：Usefulness of Controlled Attenuation Parameter for Identification and Grading of Nonalcoholic Fatty Liver Disease in Adolescents with Obesity

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Objective To identify controlled attenuation parameter (CAP) based cutoffs for diagnosing and grading hepatic steatosis in adolescents with overweight/obesity, using magnetic resonance imaging-proton density fat fraction (MRI-PDFF) as the reference method. Methods Adolescents with overweight/obesity were included. Fasting glucose, insulin, aspartate aminotransferase, and alanine aminotransferase were estimated. Hepatic steatosis (S) was assessed by MRI-PDFF, and graded as S0, S1, S2, and S3 with fat fraction cutoffs of = 6.0% to = 17.5% to = 23.3%, respectively. CAP and liver stiffness measure (LSM) were assessed using FibroScan. Receiver operating characteristic (ROC) curves were used to estimate the CAP scores predicting various grades of hepatic steatosis. Results A total of 108 adolescents aged 12.4 +/- 1.9 y, with mean BMI of 26.7 +/- 4.9 kg/m(2) were included. S0, S1, S2, and S3 steatosis by MRI-PDFF was identified in 15, 70, 13, and 10 adolescents, respectively. A moderate positive correlation was observed between CAP score and MRI-estimated hepatic fat (r = 0.528, p = S1, >= S2, and S3 steatosis were 271 [area under ROC (AUROC) 0.745 (0.630-0.859)], 296 [AUROC 0.820 (0.728-0.911)], and 309 dB/m [AUROC 0.836 (0.729-0.944)], respectively. Conclusion CAP score had a good discriminative ability to diagnose fatty liver in adolescents with overweight or obesity.

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《Indian journal of pediatrics》 |2022年第1期|52-58|共7页
作者
Anand Abhinav; Shalimar; Jana ManishaKandasamy DevasenathipathyKumar BrijeshSingh GajendraJain Vandana;
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作者单位

Dept Gastroenterol,All India Inst Med Sci;

Dept Radiodiag,All India Inst Med Sci;

Div Pediat Endocrinol,All India Inst Med Sci;

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正文语种英语
中图分类儿科学;
关键词
NAFLD; Hepatic steatosis; Adolescent obesity; Pediatric obesity; LSM; Elastography; HEPATIC STEATOSIS; CHILDREN; PREVALENCE; OVERWEIGHT; DIAGNOSIS; FRACTION;

Usefulness of Controlled Attenuation Parameter for Identification and Grading of Nonalcoholic Fatty Liver Disease in Adolescents with Obesity

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