A study carried out using data from the French National Healthcare Database (SNDS) examined the possible link between the occurrence of a first ischaemic stroke and use of a neuroleptic as an antiemetic: either metopimazine, dom-peridone, or metoclopramide (1). The patients included were adults who had suffered a first ischaemic stroke during the period 2012-2016, and who had been given a prescription for domperidone, metopimazine or metoclopramide during the preceding 70 days. Each patient acted as their own control. Exposure to one of these antiemetics was compared during different 14-day periods prior to the stroke. For each patient, 1 to 10 control subjects were also randomly assigned, who were matched for a range of ischaemic stroke risk factors (hypertension, atrial fibrillation, etc.), but who had not had a stroke. In this way, 2612 patients were matched to 21 859 unaffected controls (1).
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