Comprehensive Exposure Studies of Per-and Polyfluoroalkyl Substances in the General Population:Target Nontarget Screening,and Toxicity Prediction

Laihui Li; Nanyang Yu; Xuebing Wang

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Comprehensive Exposure Studies of Per-and Polyfluoroalkyl Substances in the General Population:Target Nontarget Screening,and Toxicity Prediction

机译：Comprehensive Exposure Studies of Per-and Polyfluoroalkyl Substances in the General Population:Target Nontarget Screening,and Toxicity Prediction

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Novel per-and polyfluoroalkyl substances(PFASs)in the environment and populations have received extensive attention; however,their distribution and potential toxic effects in the general population remain unclear.Here,a comprehensive study on PFAS screening was carried out in serum samples of 202 individuals from the general population in four cities in China.A total of 165 suspected PFASs were identified using target and nontarget analysis,including seven identified PFAS homolog series,of which 16 PFASs were validated against standards,and seven PFASs[4:2 chlorinated polyfluorinated ether sulfonate(4:2 Cl-PFESA),7:2 chlorinated polyfluorinated ether sulfonate(7:2 Cl-PFESA),hydrosubstituted perfluoroheptanoate(H-PFHpA),chlorine-substituted perfluorooctanoate(Cl-PFOA),chlorine-substituted perfluorononanate(Cl-PFNA),chlorine-substituted perfluorodecanoate(Cl-PFDA),and perfluorodecanedioic acid(PFLDCA n = 8)]were reported for the first time in human serum.The Tox21-GCN model(a graph convolutional neural network model based on the Tox21 database)was established to predict the toxicity of the discovered PFASs,revealing that PFASs containing sulfonic acid groups exhibited multiple potential toxic effects,such as estrogenic effects and stress responses.Our study indicated that the general population was exposed to various PFASs,and the toxicity prediction results of individual PFASs suggested potential health risks that could not be ignored.

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《Environmental Science & Technology: ES&T》 |2022年第20期|14617-14626|共10页
作者
Laihui Li; Nanyang Yu; Xuebing Wang;
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作者单位

State Key Laboratory of Pollution Control and Resource Reuse,School of Environment,Nanjing University,Nanjing 210046,People's Republic of China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
target analysis; nontarget analysis; novel PFAS; toxicity prediction; human blood;

Comprehensive Exposure Studies of Per-and Polyfluoroalkyl Substances in the General Population:Target Nontarget Screening,and Toxicity Prediction

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