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Folic acid supplementation and risk for congenital hydrocephalus in China

机译：Folic acid supplementation and risk for congenital hydrocephalus in China

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Objective: We examined whether folic acid (FA) supplementation prevented congenital hydrocephalus (CH) in more than 200 000 births in China. Design: A large population-based cohort study. Setting: All births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural birth defects regardless of gestational week were recorded. The prevalence of births with CH was classified by maternal characteristics and FA supplementation. CH was diagnosed in accordance with code 742.3 of the International Classification of Diseases, Ninth Revision, Clinical Modification, while non-neural tube defect (NTD) CH refers to CH without anencephaly (740), spina bifida (741) or encephalocele (742 center dot 0). Participants: A total of 247 831 pregnant women who delivered with known outcomes were included. Results: A total of 206 cases of CH (0 center dot 83 per 1000 births) and 170 cases of non-NTD CH (0 center dot 69 per 1000 births) were recorded in the study. The prevalence of CH and non-NTD CH was higher in women in the no supplementation group than those in the FA supplementation group (0 center dot 92 and 0 center dot 72 v. 0 center dot 75 and 0 center dot 65 per 1000 births, respectively). FA supplementation during the periconceptional period significantly prevented CH (OR = 0 center dot 29, 95 % CI 0 center dot 12, 0 center dot 69) and non-NTD CH (OR = 0 center dot 34, 95 % CI 0 center dot 12, 0 center dot 97) in northern China, especially in a high-compliance group (>= 80 %). Conclusions: Periconceptional FA supplementation did not significantly prevent CH overall in the current study. However, in the north of China with common maternal folate insufficiency, there was some evidence.

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