Triazole-Resistant Aspergillus fumigatus in an Israeli Patient with Chronic Cavitary Pulmonary Aspergillosis Due to a Novel E306K Substitution in Hmg1

Handelman Mariana; Morogovsky Alma; Liu WeiBen-Ami RonenOsherov Nir

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Triazole-Resistant Aspergillus fumigatus in an Israeli Patient with Chronic Cavitary Pulmonary Aspergillosis Due to a Novel E306K Substitution in Hmg1

机译：Triazole-Resistant Aspergillus fumigatus in an Israeli Patient with Chronic Cavitary Pulmonary Aspergillosis Due to a Novel E306K Substitution in Hmg1

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Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide, posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3- methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been associated with triazole resistance. Here, we describe a novel E306K triazole resistance-conferring mutation in the HMG-CoA reductase gene from an Israeli patient with chronic cavitary pulmonary aspergillosis (CCPA).

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《Antimicrobial agents and chemotherapy.》 |2021年第10期|共4页
作者
Handelman Mariana; Morogovsky Alma; Liu WeiBen-Ami RonenOsherov Nir;
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作者单位

Tel Aviv Univ, Sackler Sch Med, Dept Clin Microbiol & Immunol, Tel Aviv, Israel;

Peking Univ, Natl Clin Res Ctr Skin & Immune Dis, Res Ctr Med Mycol,Peking Univ First Hosp, Dept;

Tel Aviv Sourasky Med Ctr, Infect Dis Unit, Tel Aviv, Israel;

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原文格式 PDF
正文语种英语
中图分类治疗学;
关键词
Aspergillus fumigatus; Hmg1 resistance mutation; E306K substitution; triazole resistance; HMG1 mutations; antifungal resistance; azole resistance; mycology;

Triazole-Resistant Aspergillus fumigatus in an Israeli Patient with Chronic Cavitary Pulmonary Aspergillosis Due to a Novel E306K Substitution in Hmg1

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