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Biomedical Micro-/Nanomotors: Design, Imaging, and Disease Treatment

机译：Biomedical Micro-/Nanomotors: Design, Imaging, and Disease Treatment

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摘要

Untethered mobile micro-/nanomotors (MNMs), as newly-emerging attractiveand versatile nanotechnologies, are expected to be the next-generationdisease treatment tools, for breaking through the limitations of conventionalpassive drug delivery manner. However, the advances in these fascinatingplatforms have been hampered by the complexity of the biological environmentand the particularity of disease microenvironment. Consequently, specificdesign strategies and clinical imaging techniques are essential to ensurethe high-efficiency of biomedical MNMs on actuation, targeting, localization,and therapy when performing assigned in vivo tasks. This review thuscomprehensively addresses three aspects of biomedical MNMs, includingdesign, imaging, and disease treatment, highlighting the intelligent MNMswith biomimetic functionality and chemotactic capability, emphasizing theapplicability of different imaging techniques, and focusing on various proofof-concept studies based on physiological characteristics for the treatmentof major diseases. In addition, the key challenges and limitations of currentbiomedical MNMs are addressed, which may inspire future research andfacilitate translation toward clinical treatment.

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