Erythrocyte Associated Amyloid-beta as Potential Biomarker to Diagnose Dementia

Lauriola Michele; Paroni Giulia; Ciccone FilomenaDOnofrio GraziaCascavilla LeandroParis FrancescoGravina CarolinaUrbano MariaSeripa DavideGreco Antonio

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Erythrocyte Associated Amyloid-beta as Potential Biomarker to Diagnose Dementia

机译：Erythrocyte Associated Amyloid-beta as Potential Biomarker to Diagnose Dementia

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Background: Although it is known that Alzheimer's disease (AD) is associated with the progressive accumulation of amyloid beta-peptide (A beta) in the human brain, its pathogenic role has to be completely clarified. A beta moves from the bloodbrain barrier to the plasma and an increased A beta production in brain could be associated with higher A beta concentrations in blood. A recent study has evaluated A beta 40 and A beta 42 levels in human red blood cells (RBCs) with evidence of age dependent higher A beta concentration in RBCs.

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来源
《Current Alzheimer research》 |2018年第4期|381-385|共5页
作者
Lauriola Michele; Paroni Giulia; Ciccone FilomenaDOnofrio GraziaCascavilla LeandroParis FrancescoGravina CarolinaUrbano MariaSeripa DavideGreco Antonio;
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作者单位

IRCCS Casa Sollievo Sofferenza, Complex Unit Geriatr, Dept Med Sci, I-71013 San Giovanni Rotondo;

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原文格式 PDF
正文语种英语
中图分类神经病学与精神病学;
关键词
Alzheimer's disease; cognitive impairment; amyloid beta peptide; biomarker; erythrocyte associated-A beta 42; A beta 40;

Erythrocyte Associated Amyloid-beta as Potential Biomarker to Diagnose Dementia

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