Causal analysis of serum polyunsaturated fatty acids with juvenile idiopathic arthritis and ocular comorbidity

Shu Qinxin; Zhao Chenyang; Yu JingLiu YusenHu ShuqiongMeng JiayuZhang Jun

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Causal analysis of serum polyunsaturated fatty acids with juvenile idiopathic arthritis and ocular comorbidity

机译：Causal analysis of serum polyunsaturated fatty acids with juvenile idiopathic arthritis and ocular comorbidity

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Background & objective To investigate the causal effects of plasma Polyunsaturated fatty acids (PUFAs) on the risk of juvenile idiopathic arthritis (JIA) and ocular comorbidity through Mendelian randomization (MR) analysis. Methods Genetic variants (formerly single nucleotide polymorphisms, SNPs) that are strongly associated with PUFAs levels (P 0.05). In further MR analysis, results from model 2 also showed a consistent trend. Besides, multiple sensitivity analyses revealed that there was no obvious evidence for unknown pleiotropy (P > 0.05). Conclusions Our MR study provides genetic evidence on the possible causality that plasma LA level might protect against JIA associated iridocyclitis, whereas AA was responsible for opposite effect.

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来源
《European journal of clinical nutrition》 |2023年第1期|75-81|共7页
作者
Shu Qinxin; Zhao Chenyang; Yu JingLiu YusenHu ShuqiongMeng JiayuZhang Jun;
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作者单位

Chongqing Medical University,Chongqing Med Univ;

Affiliated Hosp 1,Chongqing Med Univ;

Wuhan Aier Eye Hosp,Wuhan Univ;

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原文格式 PDF
正文语种英语
中图分类营养卫生、食品卫生;
关键词
MENDELIAN RANDOMIZATION; FISH-OIL; DISEASE; ASSOCIATION; UVEITIS; PROFILE; RISK;

Causal analysis of serum polyunsaturated fatty acids with juvenile idiopathic arthritis and ocular comorbidity

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