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首页> 外文期刊>Advanced functional materials >Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation
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Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation

机译：Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation

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摘要

Cordycepin (3′-deoxyadenosine) has a demonstrated value in amelioratingnonalcoholic steatohepatitis (NASH); however, its short in vivo metabolismtime and high dose-induced cytotoxicity are challenges limiting its clinicalapplication. Herein, a cordycepin-loaded macrophage vesicle (C-MV) isdeveloped for targeted cordycepin delivery to achieve stable and durablemitigation of NASH. The C-MV is obtained using cytochalasin B-stimulatedRAW 264.7 cells to produce MV, followed by repeated freeze-thawing andextrusion of MV and cordycepin. C-MV selectively delivers cordycepin tomacrophages at the site of liver injury, slowly releases cordycepin, reducesthe toxicity associated with high cordycepin doses, and increases the mice'ssurvival rate from 40% to 90%. Moreover, C-MV reduces liver apoptosis andattenuated NASH liver injury by activating AMP-activated protein kinase andinhibiting caspase 6 activity. Overall, C-MV exhibits better anti-inflammatory,lipid-lowering, and anti-apoptosis properties than free cordycepin, making it apromising delivery system for the potential clinical application of cordycepin.MV combined with cordycepin provides an inspiring bionic strategy for NASHtreatment that can achieve effective therapeutic effects in vivo.

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