Immunological configuration of ovarian carcinoma: features and impact on disease outcome

Jitka Fucikova; An Coosemans; Sandra OrsulicDavid CibulaIgnace VergoteLorenzo GalluzziRadek Spisek

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Immunological configuration of ovarian carcinoma: features and impact on disease outcome

机译：Immunological configuration of ovarian carcinoma: features and impact on disease outcome

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Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.

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《journal for immunotherapy of cancer》 |2021年第10期|1-26|共26页
作者
Jitka Fucikova; An Coosemans; Sandra OrsulicDavid CibulaIgnace VergoteLorenzo GalluzziRadek Spisek;
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作者单位

Sotio Biotech;

Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol;

Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, Leuven Cancer InstituteUCLA David Geffen School of Medicine and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los AngelesGynecologic Oncology Center, Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University HospitalDivision of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospital LeuvenDepartment of Radiation Oncology, Weill Cornell Medical CollegeSandra and Edward Meyer Cancer CenterCaryl and Israel Englander Institute for Precision Medicine;

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正文语种英语
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关键词
female; genital neoplasms; immunologic surveillance; immunotherapy; tumor biomarkers; tumor microenvironment;

Immunological configuration of ovarian carcinoma: features and impact on disease outcome

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