Efficacy of BCG vaccine in animal models of neurological disorders

Cossu Davide; Ruberto Stefano; Yokoyama KazumasaHattori NobutakaSechi Leonardo A.

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Efficacy of BCG vaccine in animal models of neurological disorders

机译：Efficacy of BCG vaccine in animal models of neurological disorders

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The Bacillus Calmette-Guerin (BCG) vaccine can modulate the immune response via antigen-specific immune response, but also it can confer nonspecific protection and therapeutic benefits in several neurological conditions through different heterologous effects of vaccination. However, the precise mechanism of action of BCG remains unclear. In this review, different mechanisms underlying BCG-mediated immunity will be explained in animal models that reflects characteristic feature of neuroinflammatory and neurodegenerative disorders such as multiple sclerosis, Alzheimer's and Parkinson's diseases. Furthermore, evidence for a beneficial effect of the BCG on neuropsychiatric disorders, will be also discussed. (C) 2021 Elsevier Ltd. All rights reserved.

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来源
《Vaccine》 |2022年第3期|432-436|共5页
作者
Cossu Davide; Ruberto Stefano; Yokoyama KazumasaHattori NobutakaSechi Leonardo A.;
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作者单位

Juntendo Univ;

Univ Sassari;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
BCG; Neuroprotection; Experimental auto immune; encephalomyelitis; Alzheimer's disease; Parkinson's disease; Neurocognition; BACILLUS-CALMETTE-GUERIN; CENTRAL-NERVOUS-SYSTEM; T-CELLS; APP/PS1 MICE; MOUSE MODEL; INFECTION; IMMUNIZATION; COMBINATION; SUPPRESSION; DEPRESSION;

Efficacy of BCG vaccine in animal models of neurological disorders

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