Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis

Gilbertson Sarah E.; Weinmann Amy S.

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Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis

机译：Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis

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Model organisms such as mice are important for basic research and serve as valuable tools in preclinical translational studies. A challenge with translating findings from mice to humans is identifying and separating evolutionarily conserved mechanisms in the immune system from those diverging between species. A significant emphasis has been placed on defining conserved gene regulation principles, with divergent mechanisms often overlooked. We put forward the perspective that both conserved and divergent mechanisms that regulate gene expression programs are of equal importance. With recent advances and availability of datasets, immunologists should take a closer look at the role for genetic diversity in altering gene expression programs between mouse and human immune cells.

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来源
《Trends in immunology》 |2021年第12期|1077-1087|共11页
作者
Gilbertson Sarah E.; Weinmann Amy S.;
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作者单位

Dept Microbiol,Univ Alabama Birmingham;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
TERT PROMOTER MUTATIONS; TRANSPOSABLE ELEMENTS; STRUCTURAL VARIATION; COLLABORATIVE CROSS; INNATE IMMUNITY; T-CELLS; EXPRESSION; REVEALS; DOMAINS; MICE;

Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis

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